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How many years does Pluvicto extend overall survival
Prostate Cancer | Last Active: 3 days ago | Replies (9)Comment receiving replies
"How many years does Pluvicto extend overall survival?"
If you look at the VISION trial, the answer is "a median improvement of 4 months".
But I wouldn't interpret that too narrowly: everyone in the trial had metastatic cancer that had reached castrate resistance, then had received chemo at least once, and in many cases (I'd guess) was receiving Pluvicto as a final hail-Mary because the chemo had failed to stop the cancer from progressing. Also, half of the patients still did better than 4 months (many, perhaps a *lot* better), and there was no upper age limit for the trial that I can find, so a non-trivial portion of the participants likely died of something other than prostate cancer.
So don't be discouraged by that number, because interpreting stats is tricky.
https://www.nejm.org/doi/full/10.1056/NEJMoa2107322
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I was in the 2021-22 Pluvicto clinical trial in the US. At that time, and I believe this is still the case, Pluvicto was shown to "extend life 11 to 15 months".
It knocked my cancer back for 22 months. I then received ARC targeted beam on three troublesome tumors. That helped for a few more months. I was then selected to repeat the full 6 Pluvicto treatments starting in the fall of 2024. After 4 of the repeat 6 treatments, it again has greatly reduced the cancer, related tumors, etc. and I am doing great. So good, the last 2 treatments have been paused for the last 4 months. I will receive the remaining 2 when needed, hopefully not before mid 2026.
So, to summarize my response to a couple of questions, 11 to 15 months and I am a lucky patient who has responded extremely positively and doing as well as most any Pluvicto patient.
Good luck, do your research.