@cicihi4
My own experience and reading post like yours about being on immunosuppressants possible causing SCCs.

All but one of my skin cancers (around 10) were BCC. I went through 30 rounds of radiation for prostate cancer in 2023. I had read it can affect your immune system as it puts a lot of strain on the body.

Then I got my first SCC months after my treatments ended. I had never had a SCC and all BCC were in sun damaged area. The SCC was not in a sun damaged area. The dermatologist said it was most likely caused by HPV virus.

I was shocked and inquired about it as had been monoquomos (spell) for over 40 years. I was told almost all adults have HPV and usually remain dormant. I then enquired further and was told you can pick it up in locker rooms and other situations not just from intimacy.

There was a poster on MCC who had come down with a medical issue who posted about his doctor saying radiation can cause immune issues as body fights the damage. I am not sure what his medical issue was (forget) but the doctor associated it with receiving radiation affecting his immune system.

I am not a medical professional at all but I keep reading and from my own personal experience keep reading the role of immune system and SCC caused by HPV.

If anyone knows of a study about his possible connection would surely like to read it. I am coming up on my 2nd year after my radiation treatments.

I had a maternal uncle who lived to just short of his 95th birthday. He was treated for Hairy Cell Leukemia for the last 20-25 years of his life with, among other thigs, Interferon by infusion, whenever his platelet level required it. He also had major squamous cell carcinomas (SCC) on the tops of both ears. The top half of his ears were missing for at least 5-10 years. I always assumed he got the SCCs from working outside in construction most of his life and wearing a baseball type cap, which exposes the tops of ears. He let the last one go for so long that it spread down his cheek into the lymph nodes in his mouth. The surgery and treatment left him with a lack of saliva and the loss of his taste buds. After being separated by 400 miles for 40 years, I moved closer, and I took him shopping every couple of weeks and to dinner afterwards and he would complain about the food having no flavor.
Now, I'm wondering if the immunotherapy he received for so many years played a role in his SCCs. It's been 15 years since he passed, and I don't remember him having any other skin cancers but it's not likely it would have been something he talked about.