anyone had endo suggest taking Yorvipath after tymlos?

Interesting (new?) drug @zygote.

Sorry to hear that you're still having some issues to work through, but yay, you had made through one year!

From what you wrote, it seems that you don't have good functional parathyroid glands left? If so, does it mean you don't really need any antiresorptive drugs after you finish Tymlos? What's your baseline bone turnover marker readings if you have them tested and don't mind sharing?

My remaining parathroids work, but not enough to keep my Calcium within normal without some help My endo has not yet discussed any antiresorptives after I finish the Tymlos, I'm guessing that the Yorvipath would be in addition . I didn't ask that question because I was thrown off when I heard MORE SHOTS after Tymlos. ug. and ug.
My first P1NP was 715 ng/ml
6 months later P1NP is 250 mcg/ml
CTX is 1213 pg/ml
frustrating to have them all measured in different units.. converting 250 mcg /ml =250000ng/ml so my P1NP went up.
Im planning on fosamax because I have problems with my teeth. Just came back from having a CT of a tooth. lost a lot of bone around it and need it pulled.

The units for P1NP from your two labs are inconsistent which might be a problem. My P1NP from Quest uses mcg/L, which is the same as ng/ml. The reference range is 22-104 mcg/L for women 29-45 and 30-110 mcg/L for men under 60. Your second P1NP 250mcg/ml (=250,000ng/ml as you pointed out) is a HUGE number - not possible!? I say this because when one of mine P1NP came back high in the 400s during Forteo treatment, my endo ordered additional labs to rule out other causes.

Was your P1NP 715 ng/ml before or after Tymlos treatment?

It's good that your remaining parathyroids are working! Might it be that your endo is considering Yorvipath, a new drug for your slight hypoparathyroidism after tymlos? You could be among the first to use it.

Thank you for your response. It gave me pause and I spent some time really looking at my results. Your lab is measured in Liters, mine in milliliters. I tried converting my results to Liters and it's nutty .. a negative number. I had asked for a P1NP which, apparently, he had never ordered because he couldn’t find the code in Quest and ordered it in LabCorp. But I see now- that the lab he ordered was a propeptide type 1 collagen, not a procollagen type 1 intact N terminal peptide. Looking up the differences it says : Procollagen type I intact N-terminal propeptide (PINP) and propeptide type I collagen both relate to bone formation but differ in their detection and clinical uses. P1NP refers to the intact N-terminal propeptide of type I procollagen, while propeptide type I collagen can refer to either the N-terminal or C-terminal propeptides released during procollagen processing. P1NP is a sensitive marker for bone formation and is often used to monitor osteoporosis and bone health.
Feb 2025 the labs from LabCorp result of 715 was propeptide type 1 collagen. (7months of Tymols)
May 2025 labs were from Quest and the result of was P1NP 250mcg/ml and CTX. 1213pg/ml
Confusing, but it makes me feel better knowing that the high number of 715 really was not a P1NP but a differnt marker .

I just asked my son to do the math. I'm way off. P1NP 250mcg/ml= 250,000 mcg /L . if that is correct ..yikes.

Thank you for your response. It gave me pause and I spent some time really looking at my results. Your lab is measured in Liters, mine in milliliters. I tried converting my results to Liters and it's nutty .. a negative number. I had asked for a P1NP which, apparently, he had never ordered because he couldn’t find the code in Quest and ordered it in LabCorp. But I see now- that the lab he ordered was a propeptide type 1 collagen, not a procollagen type 1 intact N terminal peptide. Looking up the differences it says : Procollagen type I intact N-terminal propeptide (PINP) and propeptide type I collagen both relate to bone formation but differ in their detection and clinical uses. P1NP refers to the intact N-terminal propeptide of type I procollagen, while propeptide type I collagen can refer to either the N-terminal or C-terminal propeptides released during procollagen processing. P1NP is a sensitive marker for bone formation and is often used to monitor osteoporosis and bone health.
Feb 2025 the labs from LabCorp result of 715 was propeptide type 1 collagen. (7months of Tymols)
May 2025 labs were from Quest and the result of was P1NP 250mcg/ml and CTX. 1213pg/ml
Confusing, but it makes me feel better knowing that the high number of 715 really was not a P1NP but a differnt marker .