Evenity and bowel movements
Hello
I started once a month Evenity in March 2025.
I’ve had 3 injections so far …so far so good
I’ve noticed my bowel movements are VERY soft …not frequent like diarrhea just very soft pile ( sorry too much information )
Anyone else experience this as a side effect?
Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.
You may want to ask about how Evenity disrupts the microbiome (gut), the doctor may have the latest data on this. What I found was this:
“While Evenity's primary action is on sclerostin and the WNT pathway, it is hypothesized that this could indirectly affect the gut microbiome through the WNT pathway, particularly by potentially influencing the levels of SCFAs like butyrate produced by certain gut bacteria. This potential interaction is a subject of ongoing research, and its precise nature and significance are still being explored.”
About:
“Wnt Pathway and Microbiome: The Wnt pathway plays a significant role in bone development and health. It is also known that the gut microbiome, particularly bacteria like Lactobacillus rhamnosus, produce short-chain fatty acids (SCFAs) like butyrate, which can influence this pathway.
Butyrate and Bone Formation: Butyrate has been shown to potentially promote bone formation by activating osteoblasts and inhibiting osteoclast differentiation.”
(These answers were from an AI response, so there is no one link to share. I use the AI response as a jumping off point, and go search for more detail using the terms included in the response).
Lactobacillus rhamnosus is found in many yogurts.
I haven’t taken Evenity, and apologize for jumping in here, but I like to research info that might help me make a decision later on. I’m on Reclast right now.
And, after having issues with poo, I found the Bristol Stool Chart which is what most doctors use to identify poo. I found it a little easier to say that I had a #5 level on the Bristol chart than having to describe it to the nurse, the doctor, etc. The chart is easily found on the web, phone search in the waiting room works when you need it. It’s evidently used as an international standard. Who knew!?
https://www.prevention.com/health/a20441452/7-textures-of-poop-and-what-they-mean/
Wow
Thanks so much for the information 🥰
Never heard of Bristol chart
Good to know
Could you please share your experience with Reclast? When I finish Tymlos in April next year, apparently that is the drug my doctor recommends. And after Reclast, can we stop taking bone drugs?
@susanjohnston I’ve had 2 annual infusions, third one is coming up next week. Original plan was to do the three. I would expect 2 years off, then see. About 30 hours after the infusion I feel like I have a mild flu, headache, some body aches, lasts about 12 hours. Then no other side effects.
I see a local endocrinologist who handles the infusion, and a MD Anderson rheumatologist follows me and orders the DEXA at their facility. Once I started doing bone density there he really likes me to go back for consistency. I have video calls with him now, not in person. They are both happy with current status even though my spine increased 6% then dropped the next time. But it’s still better than it was. I attached a screenshot of my scores, if you’re interested.
I don’t take any calcium, it hurts my stomach and never seemed to help. I do eat a lot of foods with calcium and the docs seem okay with that. I take D3 2000 iu everyday. I now go to the gym 2-3x week, walk for 45 min 4-5 days, and do Taichi 3x a week. I know I need to do more strength training and are (slowly) adding it into gym visits.