Hi Aubreybill. I started on 200 mg of Verzenio twice daily. I lost my taste, my appetite, I had diarrhea, upset stomach, stayed in bed most of the day. I couldn't use metal forks, knives so I went to plastic everything, helped a tad. Lost some weight, couldn't gain weight, so my oncologist changed my dosage to 100 mg twice daily. After about a week, I started feeling like myself again. Now I'm eating like a horse, taste is back, no diarrhea or upset stomach. I believe Protocal is to start on 200 mg but 100mg worked best for me, at my oncologists' recommendation. I'm now doing great. Good luck to you. Just write down every little thing that happens to you, for your doctor. Blessings dear girl!!!