For me, the first 8 weeks on Orgovyx caused the worse side effects. Fatigue in the afternoon, low libido and brain fog. Occasional hot flash. These side effects have gotten much less bothersome in my third month of Orgovyx. Better energy (I’m exercising 6x/week), and less brain fog. Low libido still an issue. Maybe I’m getting used to the “new” normal or maybe the exercise is really kicking in. Anyway, I wish you great luck as you navigate these waters.