I, too, have considerable neuropathy in my feet (and hands). I use a cane to walk if going long distances just for balance and stability. I have no other side-effects from the Padcev I take, however, so consider myself lucky except for the neuropathy. My oncologist told me if I were to go off the Padcev that my cancer would quickly recur. So, it looks like I will be on the Padcev indefinately at this point. I just hope the neuropathy does not worsen. Mostly me feet feel like they are in cement and numb. Weird. My grip strength in my hands has lessened as well. But, I feel good otherwise. So, I feel it is a small price to pay to keep my cancer at bay.