Hi @bethrva, and welcome to Mayo Clinic Connect! I am sorry you are experiencing all-over symptoms after taking Repatha. You are so wise to recognize and report it to your doctor right away. A lot of people have great success with Repatha. However, your experience certainly also sounds reasonable and there are other options.

I believe the half-life of this drug is somewhere between 14-17 days, so the amount in your body will increase with your second dose. It will also take several months to get out of your system.

I have genetically high cholesterol and my highest untreated LDL over the years has been what you say your cholesterol is. I took a 3 month break from Repatha after my experience with the drug. Side effects had crept up on me and I got a wake-up call the night after my 9th injection. I thought I felt better after this break and briefly tried Praluent one time, then was done. I quit taking all cholesterol drugs and started LDL apheresis treatments every other week that removed cholesterol from my blood, a process similar to dialysis. I agreed to try Repatha again and it was miserable. Fast forward to now as a cardiology patient at Mayo Clinic MN, my cholesterol is under control for the first time ever AND no more apheresis treatments. It has been a rough road. My encouragement to you is to stay as active as you can through this process.

- You may want to ask your doctor about inclisiran. I was told it is the same as Repatha but in my experience (and my current doctor’s explanation) it is not. https://www.drugs.com/medical-answers/difference-between-leqvio-repatha-3571911/
- I have utmost confidence that Mayo Clinic Cardiology can help you. You may want to contact them to see what your options are. http://mayocl.in/1mtmR63

Is 375 your total cholesterol? If you are comfortable sharing, do you have other challenges with your health?