MorganJane:

Just read this and I have had a similar situation with Paxil. Was utilizing 12.5 CR for 17 years successfully. Then, following a surgery I had intense panic and anxiety. It was almost like I went off of the Paxil all at once. That has been a year ago, and I have tried other medications through a psychiatrist, but nothing seems to lift this depression and anxiety. The first try was to up the Paxil CR dose and that failed. It almost seems like we get one shot with SSRI medications. It is almost like the first medication makes you treatment resistant in the future. I am weaning off the Paxil now which is causing increased depression. The anxiety is sort of constant especially in the mornings. Since weaning, my Doctor has me trying one more SSRI, Celexa , to try to break this cycle and lower the depression. And before everyone piles on, I have tried all the alternative methods; TMS, brain retraining, acupuncture, detox, neurofeedback, mindfulness.

Did not get brain zaps; maybe the Paxil was not really working anymore. I have found through research that Paxil use inhibits one of the key metabolizing enzymes used in a lot of phych meds. This is the reason I am trying Celexa because it uses a different primary enzyme. Also did the Gene site test.

Hope you have found some relief.

Just praying that I get some relief from The Celexa. Zoloft and Pristiq did not yield results.