Connect
← Return to Promising research results for treatment of aggressive PC
Discussion
Promising research results for treatment of aggressive PC
Prostate Cancer | Last Active: Jun 4, 2025 | Replies (5)Comment receiving replies
If there is really something to this, why, when it was published in 2018, there weren’t treatments created by 2025.
There are no trial as of now of ISRIB or related drugs.
The article said
The researchers hope that this discovery will quickly lead to clinical trials for ISRIB or related drugs for patients with advanced, aggressive prostate cancer. “Most molecules that kill cancer also kill normal cells,” Ruggero said. “But with ISRIB we’ve discovered a beautiful therapeutic window: normal cells are unaffected because they aren’t using this aspect of the UPR to control their protein synthesis but aggressive cancer cells are toast without it.”
Something must not have worked as hoped.
Replies to "If there is really something to this, why, when it was published in 2018, there weren’t..."
Connect
That's the problem with overhyped, misleading headlines like "Research Finds ‘Achilles Heel’ for Aggressive Prostate Cancer." There are a few reasons we're not there yet:
- that was very early-stage research in 2018
- ISRRIM may have serious or even catastrophic long-term side-effects that we don't fully understand yet, so they're going cautiously before human trials
- most of the research interest and investment in ISRIB is centred around treating Alsheimer's https://en.wikipedia.org/wiki/ISRIB
- the early research cited in the article is specific to castrate-resistant prostate cancer that involves the MYC genetic mutation and PTEN-suppression mutation in combination