My doctor has said and I have also heard from the experts on the migraine world Summit that sometimes when one CGRP medication doesn’t work another one will. I’ve also heard that Vyepti is probably the one that works the best, but there are more issues with most people getting it covered with insurance. However, sometimes it’s actually an easy one to get on Medicare because it doesn’t go through your prescription coverage. It goes through part B. Just ideas to talk to your doctor about. Good luck!