My psych put me on mirtazapine and upped my wellbutrin to 300 verses 150. At first it seemed to be okay but after a week I started having leg pain in my calf. So I looked it up and it said that was a severe side effect plus if you have restless legs,which I do, you should not take it. So when I told him about it he dismissed me like there was that small amount could do that. So what I did was stop the mirtazapine and it went away. I also sent him the information, side effects in a text and his response was ,okay let me know how you make out. I'm not going back to him again.