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"Recombinant monoclonal antibody" technology is way over my head. I was told Actemra was derived from the blood of a mouse. That made me think Actemra wasn't a good idea but I got over it. Actemra works extremely well for me with no discernible side effects.
https://www.biointron.com/blog/what-are-recombinant-monoclonal-antibodies-a-biotech-primer.html#:~:text=DOI%3A%2010.1533%2F9781908818041.357,agents%20to%20target%20an%20antigen.
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Unlike the good people in the UK, I have used Actemra for 6 years to treat PMR. My symptoms return when I don't do my monthly infusion. My rheumatologist has no plan to stop my Actemra infusions unless Actemra stops working. At this stage, my rheumatologist said something about "immune system memory" and it is unlikely that my autoimmune conditions will ever go away.
Some of my Prednisone side effects have improved but not all of them. My rheumatologist doesn't think Prednisone is good for me anymore. He says Actemra is better for me. I would wholeheartedly agree!
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You posted somewhere about your tapering schedule once you were on Actemra but I can't find it. I am getting monthly infusions of Tyenne after 2 years of steroids and Methotrexate not being able to get me before 10mg of steroids. I started feeling the good effects of Tyenne within a week of my first infusion and am scheduled for my third one this week. I'm asking about your taper schedule because I'd like to go as fast as safely possible. My rheumy wants me to just drop by one mg every two weeks - which seems too slow to me! I know everyone is different but I'm feeling great and impatient to leave the steroids behind!