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Perineurial invasion. 1 out of 10 samples cancerous. Treatment?
Prostate Cancer | Last Active: Jun 5 8:56pm | Replies (25)Comment receiving replies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221308/
Ambiguity and Contradiction rules the day! Here’s another, co-authored by my RO at Sloan. I guess we are so accustomed to the word ‘invasion’ having dire consequences, we just assume it’s another nail in the coffin.
When I read my biopsy report and saw PNI on 6 out of 12 cores, I figured it was lights out for sure.
Phil
Replies to "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221308/ Ambiguity and Contradiction rules the day! Here’s another, co-authored by my RO at Sloan. I..."
These are the kinds of studies that are not very interesting. They only look at favorable gleason scores at biopsy and see if PNI has an effect on upgrading, i.e., that pattern 4 was missed at biopsy. It does not say that PNI in the pathology has any independent effect on outcomes.
I was 11 out of 14 with a Gleason 9 and I still feel fine, though I struggle with fatigue and weight gain while on ADT…
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And yet PNI does not appear to be representing that cancer is more aggressive.
From the above video conclusions
‘These findings suggest that in this setting, biopsy PNI alone should not be a concern for more aggressive disease requiring pathologic confirmation or intervention.”