When I stopped taking my antidepressant combo, it was my 4th time taking it. Even though I told my psychiatrist that it was ineffective when I retried it the 2nd time. I think the psychiatrists had me trying and retrying them because they didn't know what else to put me on. I have no residual effects. I went off because my psychiatrist dropped me and the meds were completely not working. There was no change from taking them to not taking them.