Well, you could come off treatment and then actively monitor with labs, consults and depending on insurance imaging.

The frequency of those, discuss with your medical team, likely every three months for consult and labs, six to 12 for imaging.

There are isolator continuing, castrate resistance, the side effects, impacts to your systems - organ, bone...the impacts to bone, organs can be monitored and mitigated.

There are different schools of thought on curing advanced PCa. Let's hope your medical team is right but have a plan for lifelong management!

If you come off treatment, one benefit may depend on T recovery, how long it takes vice how long your PCa takes to get active again. That's an unknown, baseline T, age, duration of ADT.

One scenario is you cone off treatment, your T is slow to recover but your PCa is not, then, what have you gained? Then again, the opposite could occur, T recovers quickly, PCa slumbers along much longer, life with T is good, that we know!

The two tines I've been on ADT have not gotten in the way of what I do, just how I feel doing it.

There are mitigating strategies that you control:

Diet
Exercise
Managing stress.

As other indicate, your medical team has some medical aids to mitigating the side effects too.

There is no right answer here. There are good answers based on guidelines such as NCCN and AUA, the "science." There is more clinical data in a multitude of clinical trials too.

If you have confidence and trust in your medical team, consider their recommendations in your decision making!

Kevin