My alkaline phosphatase was the main culprit - my highest that I can recall was around 260-something. I’ve also had a positive test for anti-mitochondrial antibodies, and the combination is like putting PBC in lights (my words, haha). The Urso does help that alk phos number decrease, but my doctor said that the newest guidelines are for that number to be under 100 and I just don’t get there. I’m also taking fenofibrate to help, though I personally can’t remember how. He’s attempted to have me take different, more recently approved medications, but my insurance always denies it.
As far as doing other tests for staging, I’ve had ultrasounds and other types of bloodwork done - haven’t had a biopsy since that first one in 2008.
I just would like to add, for anyone else who may read this, that I know that not everyone likes the same things or people, but I can only speak about my own positive experiences with such a confusing diagnosis and just hope that a recommendation may help someone else, too. Even if it leads down a path where someone might be able to find more information or discover more answers, that’s why I’m sharing my doctor’s information.

Dr. Michael J. Ryan, MD
Capital Digestive Care
I’ve included a couple of links. Always worth reaching out to him. Hope this helps!
https://www.capitaldigestivecare.com/doctors-providers/michael-ryan/
https://connect.medicalnewstoday.com/provider/dr-michael-ryan-1962488668