When you take abiraterone it stops your body from Producing cortisol. The prednisone replaces the cortisol. Without it, you would have tremendous fatigue and a lot of other problems like weakness, loss of appetite, and unintentional weight loss. In severe cases, low cortisol can result in low blood pressure, dizziness, and even fainting. If left untreated, it can lead to a life-threatening condition called adrenal crisis.

You must take prednisone or an equivalent.

Prednisone is not the reason you need to take Xgeva. It actually has nothing to do with it.

Abiraterone reduces your testosterone to almost nothing and that results in your bones deteriorating. Lupron also does this if used alone. That is what causes the problem and the reason you have to take Xgeva. Zometa Does the same thing and it has a Lower risk of causing jaw problems, That’s what my oncologist prescribed for me.

Stopping prednisone will not help you at all.