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DiscussionAnyone taking cyclin-dependent kinase (CDK) 4/6 inhibitors?
Breast Cancer | Last Active: Jun 20, 2025 | Replies (38)Comment receiving replies
Replies to "72 female - had early stage breast cancer diagnosis 30 years ago - mastectomy for both..."
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I have been on Ibrance and letrozole for nine years now. The only side effect that I have had since the outset has been loose stools in the morning. I vaguely remember having fatigue when I started, but even at age 81, have a good energy level. My initial dosage of Ibrance was 125 mg, but it was gradually reduced down to 75 mg within about a year because of neutropenia. I wish you the best with your decision. Wonder if a second opinion would help?