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Trimex Issues

Prostate Cancer | Last Active: Nov 10, 2025 | Replies (11)

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Profile picture for Jeff Marchi @jeffmarc

I thought somebody might post this information but they didn’t so I will. Not my words

Alprostadil, one of the ingredients in Trimix, causes a painful reaction in 20% of men who use it. Increasing the dose only makes it worse. After experiencing the same painful reaction as you have, I am now using a low-alprostadil version of Trimix. The discomfort, though still present, is at a much lower intensity and more tolerable. Another option is Bimix which contains no alprostadil.
https://menmd.com/injection-therapy-guide-for-erectile-dysfunction/

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Replies to "I thought somebody might post this information but they didn’t so I will. Not my words..."

Yes , you’re right have heard that about Trimex so Dr. changed my prescription to Bimex which will arrive next week but here’s a question for those with experience, can these shots work if you’re still 6 weeks from my second Lupron shot to wear off , I’d like to think the Dr .would have said wait till Lupron has expired but since he didn’t I assume some of you have experience and success even still being under the effects of Lupron? Look forward to hearing results under these conditions

@jeffmarc I had a turp as a young man and wish I would have had sought a 2nd opinion. Anyway, it ruined my sex life and I haven't had sex with my wife for 3 years because I can't get an erection. I have started down the trimix road and the first batch did nothing so he bumped me up to 20/40/2 strength of alprostadil/papaverine/phentolamine)/ml. Of course I am in the 20% who reacts to alprostadil and get aching dick disease (ADD). The stuff is also not working yet. I injected 70 units last night and my unit was pretty full and firm but not pointing the sky so it is hard enough to penetrate my wife's vagina. I am very frustrated and not sure I am going to get there. Anyway, thank you for raising this informaton that i saw on another trimix discussion yesterday. I just asked my Urologist to give me the highest dose of low alprostadil formulation Trimix #12 (10mcg/30mg/4mg) /mL. Do you know if they can go higher like 10/40/8? Maybe bimix would work but who knows. I just want to get hard enough have sex with my wife. I have been so frustrated and embarrassed.