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Proton, Photon, or Cryotherapy?
Prostate Cancer | Last Active: Jul 14, 2025 | Replies (28)Comment receiving replies
Believe it or not, a 2024 meta analysis was inconclusive for cognitive impairment in men undergoing ADT; even those already diagnosed showed little change.
In fact, there is some evidence that estradiol, delivered thru a transdermal patch, improved memory loss in post-menopausal women.
Yes, I know, apples and oranges, but the patch has been shown to mitigate SE’s such as cardiovascular events and liver toxicity in men; no studies have been done on cognition.
Just something to be aware of as short courses of Orgovyx (4-6 mos) are unlikely to cause further decline. Really need to speak with a KNOWLEDGEABLE oncologist about this. I emphasize this since many RO’s are not up to the newest research.
Phil
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I think you’re right 4 to 6 months doesn’t matter at all. Those of us who’ve been on ADT for many years are almost universally, saying they have brain fog. I know I sure do struggle with it after eight years of ADT,, I’ll sit here for a minute or two, trying to remember the best word or a word, Sometimes I’ll just go to the web and type in the concept so I can get the word.
Remembering facts about things is pretty easy, but remembering the names of people, drugs, and similar type of things can just be painfully slow. If the name does come to me, finally, then even more facts related to it also come with it. It can be very frustrating, I hear the same complaints from others on the multiple online chats I attend.
I just wonder what group of people they studied to find there wasn’t a definite problem with brain fog.