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Polymyalgia Rheumatica (PMR) | Last Active: 1 day ago | Replies (8)
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Replies to "Welcome @boomerlib, Here's some recent research information I found on the topic. "The interplay between genetic..."
According to the studies in the link, quite a few possibilities for causes of PMR and GCA have been explored. There's a fair bit of evidence for a genetic predisposition related to Scandinavian or Northern European ancestry. My father had GCA and PMR and I have both as well. My father's mother was of Scottish descent and my DNA test shows 7% Scottish, 5% Norwegian , the rest English and German. Women are 2-3 times as likely as men to get these diseases. My father had 3 brothers and I am the only woman in the next generation to live to greater than 70 years old, when PMR tends to occur. My father must have had a good dose of PMR genes and passed them to me! However, this doesn't explain why a husband and wife or in-laws would both get the disease.