I am just starting today. 1.5 mg day titrate to 4.5 per day within 6 weeks. For all the following conditions: chronic pain, chronic neuropathy, severe rosacea, scarring alopecia and rheumatoid arthritis. All these conditions are, in my case, caused by chronic inflammation. I get some control with prescription meds, but not enough. I am hoping LDN works and I can find a dose that is right for me. My drs did advise that in some cases 10-30 mg can be compounded to get the right dose. Your dr knows your diagnosis and what meds your already taking vs what you've tried. So your dose may seem high to some here. But, there are those who have great benefit from higher doses. I will try 4.5 mg for 4 months, if I'm getting benefit and no side effects I may try to go higher to lower or eliminate some of the prescription meds. It will take time and trial/error. Good luck on your journey.