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Can anyone share their experience with Pluvicto?

Prostate Cancer | Last Active: May 31 12:22pm | Replies (167)

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@proftom2

Interesting Pluvicto/PSA encounter after shot #3. My PSA went flying from 7 to 12. Just like that my hope deflated awaiting arrival of my PSA depression. My oncologist recommended stoping Pluvicto, and go right to scans and XTANDi. After he consulted with my Radiation Oncologist, Nuclear Oncologist, and other Oncologist, he/we/they came to the conclusion this looks like a PSA Flare. PSA Flares happen, the recommendation for the docs was to take one more injection, wait two weeks, do a Pet-Scan, and Bone scan and take it from here. This works well for me.

Anyone else have a PSA Flare-up while on Pluvicto?

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Replies to "Interesting Pluvicto/PSA encounter after shot #3. My PSA went flying from 7 to 12. Just like..."

At the last Ancan.org Advanced prostate cancer meeting one of the participants had just had his first Pluvicto treatment.

He had a lot of mets and after the treatment, the PET scan showed him much clearer, but he had terrible side effects from the Pluvicto and can’t do another session for a while, if at all. Unfortunately, I don’t recall the specifics of all of his side effects other than extreme fatigue. His PSA did go down as well.

My husband had all six Pluvicto infusions and didn't have a PSA flare, though he has had flares during and after other treatments. I know of other men who did have PSA flares during and after Pluvicto treatment. Most important is that you have had several oncologists analyze your situation and recommend that you have another Pluvicto infusion and then do scans two weeks after the infusion and decide on the path forward based on those results. It is terrific that you have had so many doctors consult on your case, and the recommendation they have made seems very reasonable. Good work by them, and by you! Good luck with your next steps.