Hi! Yea, at first it was AM and PM but I was swimming in sleepiness. I take other medications for my RLS - bupren0rphine and preg@balin. We are currently working on reducing these meds to combat the sleepiness. I love Auvelity and cannot wait to take it twice a day! I am so glad to not be crying any more, which is such a sad statement but it's true. (Are we supposed to disguise medications here? We do on a RLS site so I'm in the habit!)