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Switching from one GLP-1 RA to another?

Bariatric Surgery & Weight Loss | Last Active: Sep 28 11:55am | Replies (32)

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Profile picture for Lisa Lucier, Moderator @lisalucier

@projfan - my husband found that semaglutide (Wegovy) drops off in effectiveness for him after 6 days, as well.

You mentioned the food noise was coming back on the maintenance dose and you are managing it. What are you doing to manage it, and do you find it effective?

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Replies to "@projfan - my husband found that semaglutide (Wegovy) drops off in effectiveness for him after 6..."

Interesting that your husband has had the same experience with a six-day cycle. It makes sense given the rate at which it flushes out of the blood. I'm sure the primary reason to test a seven-day cycle was because it's so much easier for people to comply with a once-a-week schedule than a once-every-six-days pattern.

In terms of the food noise, I've found time-restricted eating is helpful -- the food noise doesn't kick in until after my first meal of the day, which I've pushed to late morning. I'm also leaning heavily into protein and fiber -- more fiber than I've ever eaten before. And a lot of processed foods still don't appeal, and I still can't handle large meals. Therefore, I eat lightly and frequently and more healthily, which so far is working out. It's been a question of building eating habits that don't make me feel deprived, because if I feel deprived, I'll be back into weight cycling.

My fallback option is going to be jacking up the dosage again. I use ozempic rather than wegovy specifically because the multi-pen lets me control the dose I'm taking. I'm maintaining at the moment at quite a low dose, which gives me room to ramp up if I need to. Also, of course, there are more options in the pipeline: https://www.primetherapeutics.com/web/primetherapeutics/search?q=GLP-1%20Pipeline%20Update.