Hi @michellesauer
Your fatigue has to be difficult, affecting everything you do and definitely a good idea to figure out what is causing it. It takes so much effort and makes it really difficult to do much else. I am not familiar with PBC, nor Ursodiol but do experience fatigue. Mine comes and goes. It can be absolutely exhausting. You are extremely strong to deal with it and taking a step in a positive direction to write this post.

Here are links I found that you may find helpful:
- a summary of PBC (Primary Biliary Cholangitis). It does look like this autoimmune has to do with the liver and fatigue can be a symptom. The treatment section states that ursodiol (Actigall, Urso) is commonly used first and helps move bile through your liver. Also, it is not likely to help with itching and fatigue. I think you are on to something worth asking your doctor about, especially since there may be other treatment options. https://www.mayoclinic.org/diseases-conditions/primary-biliary-cholangitis/symptoms-causes/syc-20376874
- Liver support group: https://connect.mayoclinic.org/discussion/liver-diseases-group-lets-connect/
- PBC lifestyle tips: https://mcpress.mayoclinic.org/living-well/primary-biliary-cholangitis-lifestyle-dos-and-donts/

What were your symptoms that led to your PBC diagnosis 8 years ago? Is it the same doctor that diagnosed it that is prescribing your Ursodiol currently?