I recently posted my results after a year on Tymlos. In short, it made a significant difference in my spine (from a T score of -3.3 to -2.6, barely osteoporotic), not so much elsewhere.

For the record, I'm 78 and had a compression fracture at L1 after a trip-and-fall in October 2023. I've done very well with side effects; had a bit of nausea after the shot for an hour or so, so I switched to doing it at bedtime and am now fine. I wasn't crazy about doing the shot every day, but it's not a big deal. The needle is very fine and very short and I usually don't feel anything, sometimes a bit of a sting for a couple of seconds. Basically, you get used to it.

I know what you mean about the whole thing being depressing. I'm also blessed to be in quite good health, but I have various orthopedic problems, garden-variety stuff but nonetheless painful, that have drastically limited my mobility and made it impossible to walk more than ten or fifteen minutes without pain. And yes, it's very depressing.

But that's separate from bone health. If you can manage the cost, I believe Tymlos is worth the inconvenience.