Yes I have great deal of fatigue weakness. It is very disabling. I thought my condition was from a gene mutation which can effect my b12 absorption and blood levels mask the issue of deficiency. Then just learned my b6 levels have become toxic levels which causes the same issues and more than b12,deficiency. The B6 toxicity has been there case of fatigue over ever had. Waiting to get in with neurologist. From research journal this may or may not ever improve. After stopping supplement it takes up to 6 months before I’ll know the permanent damages. Everyone make sure to be careful and rest fur B6 levels if supplementing. It’s often added to some meds, supplements like Magnusium bc it add boost to the absorption of it. Thus causing toxicity wo one knowing. I also have iron deficiency so it’s challenging to explain how much is PN alone. I’m sorry what you’re going thru. If I learn anything more I’ll share with you.