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DiscussionKevzara and Prednisone Tapering before and during Kevzara
Polymyalgia Rheumatica (PMR) | Last Active: 2 days ago | Replies (51)Comment receiving replies
Replies to "I'm assuming your "off label" use of Actemra is for PMR since it isn't FDA approved..."
SEMAPHORE study:
"About half of patients with steroid-dependent polymyalgia rheumatica (PMR) were able to get off steroids altogether when they were started on tocilizumab (Actemra) infusions, which also improved disease control in most cases, a randomized phase III trial showed.
In a 24-week study, 49.0% of patients assigned to the interleukin (IL)-6 inhibitor were no longer taking prednisone at their final evaluation."
https://jamanetwork.com/journals/jama/fullarticle/2796378