I had appointments at Mayo Clinic in Rochester last week. Like @roch I thought I knew my way around but the construction is massive and the detours are many. Once we parked our car at the hotel (TownPlace Suites) we decided not to drive again until our day of departure. I walked from the hotel to Mayo Clinic the first day of my appointments and even that was a maze. The second day of appointments I took the shuttle from the hotel to and from Mayo Clinic. I like to walk downtown. There are plentiful detour signs for cars but none for walking.

I don't know if the Charlton valet parking is closed. The nearest would be the Gonda valet parking. That was open when we were at Mayo Clinic last week.

Do you live in or near Rochester so this is why you are driving to Mayo? If you are staying in a hotel then I recommend a shuttle.