I went on a keto diet and took alpha-lipoic acid and after 7-8 months the feeling came back except for my toesand later added acetyl-l-carnitine and got feeling back in my toes. These all help with inflammation and carnitine can help with nerve repair.
Acetyl-L-carnitine (ALC) is a naturally occurring compound that has been studied for its potential role in nerve regeneration.
Mechanism of Action:
ALC is thought to promote nerve regeneration by:
Increasing energy production in nerve cells, Protecting nerve cells from damage, Stimulating the production of nerve growth factors, and Improving blood flow to nerves.
Evidence from Studies:
Several studies have investigated the effects of ALC on nerve regeneration. Some key findings include:
Animal studies:
ALC has been shown to improve nerve regeneration in animals with nerve injuries.
Human studies:
Small studies in humans have shown that ALC can improve pain, numbness, and tingling in people with diabetic neuropathy (nerve damage caused by diabetes).
Meta-analysis:
A meta-analysis of several studies concluded that ALC is effective in improving nerve regeneration in people with diabetic neuropathy.
Dosage and Administration:
The recommended dosage of ALC for nerve regeneration is typically 2-3 grams per day, taken in divided doses. It can be taken as a powder, capsule, or liquid.
Safety and Side Effects:
ALC is generally considered safe when taken in recommended dosages. However, some people may experience mild side effects such as nausea, diarrhea, and stomach upset.
Conclusion:
Based on available evidence, ALC may be a promising supplement for promoting nerve regeneration. However, more research is needed to confirm its effectiveness and determine the optimal dosage and duration of treatment. It is important to consult with a healthcare professional before taking ALC, especially if you have any underlying health conditions.
I have newly dx Idiopathic peripheral neuropathy. Doing alot of researching, I have NOT been able to find any positive results with ACL other than diabetic neuropathy .Anybody out there find such? Most studies with neuropathy center around diabetic neuropathy.
Some antidepressants help with numbness and pain. I also take alpha lipoic (OTC) acid which helped even more to reduce numbness. It has also helped my back pain.
I have similar symptoms..... numbness, tingling, very occasional burning.... but no real pain, and I consider that a blessing. The numbness has also affected my proprioception, so balance is an issue. One thing I have found that helps a lot is barefoot shoes. If you search for those on Amazon or google, you will find many different brands and styles. Basically, they give more room in the toe box for the toes to be able to expand, and there is less sole on the shoes so you can feel the floor/ground better. I have found some for $40 to $50 that work great. If I'm going to be walking a lot, I take my cane with me just as a precaution. Another thing I found from another member here is that AFOs (Ankle Foot Orthoses) can help with balance for some people. Again, I purchased some from Amazon made of polystyrene (hard plastic) and I wear those underneat the inserts in my shoes. I also found a used pair made of polycarbon material (thin metal) on Ebay for $200. New ones through an ortho clinic cost from $600 to $1000 each. For ME, they give me more of a sense of rigidity in my lower legs/ankles and that makes it easier to balance. Yes, I still wobble at times, but not as much. Lastly, just this week I read about something called nano socks for neuropathy. I checked on Amazon and found some that are about the same but by another brand. They are compression socks without the toe portion. I CANNOT explain HOW, but the minute I put these on, they made a difference in the way my feet feel. The ones I found are $10 a pair, so not too expensive to give them a try. I don't really FEEL them on my feet, but for whatever reason they make my feet feel more "normal." I like them so much I have ordered enough to wear them everyday. I do take them off to sleep. I hope these ideas might be helpful to someone.... or lead you to research other things that may help you with this disease. There is no cure, but if we can find something to make it a bit more bearable, that's a plus. Best wishes to all! Mike
Hello there Mike,
I’m so glad to hear the barefoot shoes work for you. I too bought a pair of the barefoot shoes and was completely surprised when I saw that each toe had its own individual insert and that the best I could do for walking in those or to put them on my feet and go into water. They were just not sturdy enough for me.
Definitely going to look into the nano socks, so thank you for that.
MoB
Hi, MoB.... the barefoot shoes I bought don't have individual to inserts. They just have a wider toe box to give the toes room to spread out. Go to Amazon and search for Grand Attack Men's Barefoot Shoes. Those are the ones I got for $40. I wound up buying several pair in different colors. Also, LEMS shoes has their own web site, and they are also great, though a bit more expensive. They have a wide toe box. The socks I got were also on Amazon.... BraceAbility Neuropathy socks. Hope they may help your feet as much as they do mine! Best wishes! Mike
Before I was diagnosed I started falling down stairs, nothing major but a twisted ankle. But one piece of advice I'll give is invest in closed toed shoes, i like cross because they are lightweight. Last year I was going up the stairs with no shoes on and stubbed my foot bad. I ended up having a small fracture in my toe. This year I fell down some stairs and hit that same toe.
I couldn't walk 2 minutes without it hurting and swelling months after so I just had surgery 2 weeks ago.
Crocs, or the like, have been lifesaver especially moving around inside. If i bump something, no biggie.
Just remember to wear them!!
I have newly dx Idiopathic peripheral neuropathy. Doing alot of researching, I have NOT been able to find any positive results with ACL other than diabetic neuropathy .Anybody out there find such? Most studies with neuropathy center around diabetic neuropathy.
Mine was also diagnosed idiopathic, I do not have diabetes.
The other thing they found in me is my B12 levels were deficient. This can cause neuropathy symptoms as well. If you are vegan it's easier to deplete your levels and levels go down as you age. I am neither so that diagnosis is also idiopathic. But I do have extensive gut problems which I assume stems from.
I take once a month B12 injection now. I'm still on gabapentin for my PN though.
ALA is in a supplement, “ Nerve Bliss” I just bought and not sure if I made the right decision. Has anyone heard of it? In addition it has B1, B12, B9, CA poppy, zinc and D3. Basic claim that enzyme MMP13 is the culprit eroding nerve’s myelin sheath and is inhibited by the B s that get delivered in ice cold water. Desperation can lead to “ why not try” decisions before checking with communities like this one.
Nerve Bliss '
I want to try this suppliment. Listened to the whole thing. New rearch found cause of neuropathy different from what has been thought. Endosed by highly respected universities & presented by a neuro doctor, who formerly had neuropathy. Sounds reasonable.
Anyone try it?
Nerve Bliss '
I want to try this suppliment. Listened to the whole thing. New rearch found cause of neuropathy different from what has been thought. Endosed by highly respected universities & presented by a neuro doctor, who formerly had neuropathy. Sounds reasonable.
Anyone try it?
Nerve Bliss '
I want to try this suppliment. Listened to the whole thing. New rearch found cause of neuropathy different from what has been thought. Endosed by highly respected universities & presented by a neuro doctor, who formerly had neuropathy. Sounds reasonable.
Anyone try it?
Welcome @4suses2, I had not heard of this though their website makes it sound good. I see folks selling it on eBay also which is a sign to me that it's just another so called neuropathy cure scam (IMHO). Their website doesn't really breakdown the ingredients but just says natural ingredients. Other red flags for me are the disclaimers at the bottom of their home page. I did see the list of ingredients in a photo of the bottle and it didn't include the 3 ingredients listed on their home page - Cinnamon Extract, Alpha Lipoic Acid and Aloe Vera Extract which is another red flag for me.
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I have newly dx Idiopathic peripheral neuropathy. Doing alot of researching, I have NOT been able to find any positive results with ACL other than diabetic neuropathy .Anybody out there find such? Most studies with neuropathy center around diabetic neuropathy.
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1 ReactionJust started taking that supplement . How long did it take to feel some relief? I am not taking any antidepressant.
Hello there Mike,
I’m so glad to hear the barefoot shoes work for you. I too bought a pair of the barefoot shoes and was completely surprised when I saw that each toe had its own individual insert and that the best I could do for walking in those or to put them on my feet and go into water. They were just not sturdy enough for me.
Definitely going to look into the nano socks, so thank you for that.
MoB
Hi, MoB.... the barefoot shoes I bought don't have individual to inserts. They just have a wider toe box to give the toes room to spread out. Go to Amazon and search for Grand Attack Men's Barefoot Shoes. Those are the ones I got for $40. I wound up buying several pair in different colors. Also, LEMS shoes has their own web site, and they are also great, though a bit more expensive. They have a wide toe box. The socks I got were also on Amazon.... BraceAbility Neuropathy socks. Hope they may help your feet as much as they do mine! Best wishes! Mike
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3 ReactionsBefore I was diagnosed I started falling down stairs, nothing major but a twisted ankle. But one piece of advice I'll give is invest in closed toed shoes, i like cross because they are lightweight. Last year I was going up the stairs with no shoes on and stubbed my foot bad. I ended up having a small fracture in my toe. This year I fell down some stairs and hit that same toe.
I couldn't walk 2 minutes without it hurting and swelling months after so I just had surgery 2 weeks ago.
Crocs, or the like, have been lifesaver especially moving around inside. If i bump something, no biggie.
Just remember to wear them!!
-
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Helpful -
Hug
2 ReactionsMine was also diagnosed idiopathic, I do not have diabetes.
The other thing they found in me is my B12 levels were deficient. This can cause neuropathy symptoms as well. If you are vegan it's easier to deplete your levels and levels go down as you age. I am neither so that diagnosis is also idiopathic. But I do have extensive gut problems which I assume stems from.
I take once a month B12 injection now. I'm still on gabapentin for my PN though.
-
Like -
Helpful -
Hug
2 ReactionsALA is in a supplement, “ Nerve Bliss” I just bought and not sure if I made the right decision. Has anyone heard of it? In addition it has B1, B12, B9, CA poppy, zinc and D3. Basic claim that enzyme MMP13 is the culprit eroding nerve’s myelin sheath and is inhibited by the B s that get delivered in ice cold water. Desperation can lead to “ why not try” decisions before checking with communities like this one.
-
Like -
Helpful -
Hug
1 ReactionNerve Bliss '
I want to try this suppliment. Listened to the whole thing. New rearch found cause of neuropathy different from what has been thought. Endosed by highly respected universities & presented by a neuro doctor, who formerly had neuropathy. Sounds reasonable.
Anyone try it?
Please let us know if this works!
Welcome @4suses2, I had not heard of this though their website makes it sound good. I see folks selling it on eBay also which is a sign to me that it's just another so called neuropathy cure scam (IMHO). Their website doesn't really breakdown the ingredients but just says natural ingredients. Other red flags for me are the disclaimers at the bottom of their home page. I did see the list of ingredients in a photo of the bottle and it didn't include the 3 ingredients listed on their home page - Cinnamon Extract, Alpha Lipoic Acid and Aloe Vera Extract which is another red flag for me.
The Foundation for Peripheral Neuropathy has a list of supplements known to help neuropathy on their list of complementary and alternative therapies here - https://www.foundationforpn.org/wp-content/uploads/2024/11/Complementary-and-Alternative-Treatments.pdf
Do you mind sharing what type of neuropathy diagnosis and treatments you have tried?
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