@brianjarvis Thanks! I clicked the link to NEJMoa2214122 and read through the webpage. After which I saw the posting by @jeffmarc suggesting to watch a PCRI video. In the video, the speaker also referenced the NEJM article. Yours and Jeff's postings are both helpful.
(https://www.nejm.org/doi/full/10.1056/NEJMoa2214122)