Hello Julie @jkhagen1 and welcome to the Head and Neck group. I do not have any experience with a g-tube, although my father had one many years ago during his treatment. He had no major issues other than irritation which was controllable with antibiotic and cortisone creams. Excessive granulation tissue seems to be unique to certain individuals. I am a veterinarian and very familiar with it in horses as they love to produce granulation tissue around wounds.. We also used caustic silver nitrate to inhibit it, or surgery, and it did not work well. My more recent experience with Manuka Honey.....a medical grade type of honey for wounds.....makes me think that it might help your situation. Open, chronic wounds will heal beautifully with it. I wonder if it would help to control the irritation from the tube that is stimulating the granulation tissue to form? That's the same theory as using the Nasacort where the steroid in it decreases the inflammation. It also inhibits bacterial growth so fights infection. You can order it on Amazon so maybe another thing in your arsenal to use?