@stuartkjones4 1. Dr. Patterson's working theory is that vascular inflammation is the root cause of LC symptoms. He has developed a blood test measuring markers that verify vascular inflammation and other things. His blood test is the first and only blood test that showed my blood was abnormal. I was out of normal bounds on 14 elements, some 100x. His approach is a series of drugs and life style changes that cure vascular inflammation. 2. All of my symptoms have improved. I had PEM, Exercise Intolerance, Brain Fog, Rocking Sensation, Head Sensation. I couldn't exercise without a crash which then caused me to sleep for hours. A couple of my more troubling symptoms was a lack of motivation and an inability to focus on things for more than about 5 seconds. I don't know if those are additional to my listed symptoms or in addition. 3. As mentioned "His approach is a series of drugs and life style changes. I would add that he states an 80% cure rate and once you are done with his program you stay cured. 4. Dr. Patterson is in Houston, and all of his appointments (and those on his team) are virtual. Full disclosure, I don't work directly with Dr. Patterson. Like any good Manager, he divides his work amongst his team by symptom type. Once your initial blood tests are available, a decision is made whether you see Dr. Patterson or another Doctor on his team. There are tons of YouTube videos with Dr. Patterson. I highly recommend you spend the hours it takes to more fully understand what is possible.