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Hans, stimulating and wry as usual and you are spot on about the patch. The more I’ve read, the more it’s made me wonder why it is not the de facto treatment for non-metastatic cases.
But I am sure some pharma marketing genius will tell R&D to add some transdermal metformin or something to the older version, call it by a nifty new name (EstraMet? MetEstra?) and sell it for the same price as Orgovyx.
Did you know that big pharma actually invented the term ‘osteopenia’ to create an illness? Its osteoporosis drug failed to increase bone density by a clinically significant amount to reverse osteoporosis but it DID increase it a tiny bit.
So marketing came up with a new ‘disease’ that their failed drug could effectively ‘treat’…you can’t make this s***t up!!😆
Phil
Replies to "Hans, stimulating and wry as usual and you are spot on about the patch. The more..."
Yes, my wife was ‘diagnosed’ with Osteopenia. When I read what that meant, I told her don’t bother, it is just like ‘pre-diabetic’. Everyone apparently is.
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you can make this shit up, provided you have a sufficiently funded marketing department, a trademark lawyer on speed dial, and a few morally flexible endocrinologists willing to ghostwrite journal articles between golf rounds.
As for EstraMet™ (tagline: “Now with bonus insulin confusion!”), I hear the Phase II trials were delayed when the patch started causing patients to hallucinate that they were actually saving money on prescriptions. Tragic side effect.
And yes, osteopenia, the gateway drug of bone diseases. It's the medical equivalent of telling someone they’re pre-bankrupt and urgently need to buy a yacht to prevent it. Pharma’s true innovation lies not in molecules, but in monetizing mild inconveniences.
Honestly, if a drug gave you seasonal depression, dry elbows, and the capacity to cry during insurance commercials, they’d just call it “Pre-Masculinity Syndrome” and suggest it runs in families. Covered by most plans, of course.
You’re right, of course, patches should be the standard. But alas, transdermal delivery doesn’t come with the same profit margin as systematically annihilating your endocrine system via a $3,000-a-month pill that also ruins your libido and your will to live.