Vitamin k2 in Managing Nocturnal Leg Cramps: A Randomized Clinical Trial. Tan J, Zhu JAMA International Medicine 2024; 184 (12): 1443-1447. My doctor found this for me. Please show this to your doctor to find the correct dose for you. You have to be careful if you also take a blood thinner. Also there are many prescription drugs that can cause restless legs. You can ask your pharmacy if any of your medications can cause restless legs. SSRIs, some blood pressure drugs can cause it, for example.