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Anastrazole and anxiety

Breast Cancer | Last Active: 1 hour ago | Replies (93)

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@jfross01

Diagnosed with ER breast cancer almost four years ago, at 38 years old. It was stage one, with no lymph node activity. I had four chemo infusions over 12 weeks. After chemo was completed, I was put on monthly Lupron injections and a daily Anastrozole pill. I did not experience many side effects of either medication until about two years ago. By the time I started experiencing side effects, I had already been taking the medications for two years. The worst side effect has been the anxiety attacks, to the point where they feel like heart attacks and I’m being rushed to the emergency room. I have had several of these now, at random times, with no explanation, over the course of two years, and it is debilitating my daily life. I have been seen by a cardiologist, and my heart is just fine. I have been seen by a neurologist, and my brain is fine. I have never really been an anxious person throughout my life, and now, I get these attack at least three times per week. My PCP has prescribed me a small-dosed Ativan as a “rescue pill,” but I don’t certainly want to have to rely on something as strong as Ativan continuously. Recently, an ER doctor brought up that it could be the Anastrozole and that with hormones being depleted and blocked, there’s nothing in my body to combat any sort of stress or adrenaline-causing situations. I don’t live a very stressful life, at all. I drink one cup of coffee per day. I don’t smoke. And I really don’t live a very exciting life. I could be sitting on the couch watching tv, and these anxiety attacks come out of nowhere. I would love to know if anyone else out there has experienced any of this with Anastrozole, and any advice or help would be greatly appreciated. Very much so!

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Replies to "Diagnosed with ER breast cancer almost four years ago, at 38 years old. It was stage..."

I am sorry you are having these problems but also interested in your post. I have been on Anastrozole for just over a year and have been experiencing worsening panic attacks and uncontrollable feelings of impending doom and uncontrollable crying for the last six months or so. My cancer diagnosis was very similar to yours and from the viewpoint of clear mammogram etc all looks well. Whilst I have had a history of panic attacks previously the current attacks are off the scale. I am becoming increasingly concerned that Anastrozole is key to these symptoms and will hope to discuss this with my oncologist at an upcoming review. I feel it maybe that patients who have previously diagnosed panic/ anxiety conditions may be more likely to experience these more extreme reactions. Possibly this could be a fruitful area for research into the side effects of AIs.

I'm 58 and had a unilateral mastectomy. I've only been on Anastrozole for 7 months, but the hot flashes - ugh. And I did see an uptick in small bouts of anxiety. What has helped me is acupuncture. University of Washington Medicine has an Osher Center for Integrative Medicine and my provider is awesome. I started with weekly visits and am down to once per month. It helps with my hot flashes, anxiety, and my overall mental health. I look forward to my visits every time. My insurance covers 24 visits per year. I really love it.