I'm age 62 and 3.5 years into this pancan battle, now stage-IV; just "got retired" on the medical grounds last month because I've used up all my leave. I wasn't ready to leave, but not able to go back full-time either. Bottom line is that I've got long-term disability insurance (and Social Security Disability) paying 2/3 of my salary until I turn 65. They (SS and my employer) both have "return to work" incentive programs and trial periods, but the terms and conditions were very ambiguous. By accepting their leave conditions, my benefits are locked in, probably for as long as I'll live. If I had remained on (semi-) active status, even with part-time allowed, I could have been subject to layoff due to a downturn in business, and lost all the benefits. With 2/3 of my salary guaranteed by insurance+SS, I'd have to work more than 27 hours at my equivalent wage every week just to break even. Given my fatigue, I can't reliably do 27-40 hours of work and perform at the level that previously justified my salary.

My advice is to make sure you have all your work-related life and medical post-retirement insurance / benefits squared away for the foreseeable future; make sure all your estate-related documents are in order; then evaluate the options for all your potential spare time.

There are folks here who have far outlived the statistics and remain NED. My experience in the Stage-IV world, trying to navigate clinical trials amidst my fatigue and other issues that crop up, is that I'm glad I'm not trying to balance all this with the performance expectations and responsibilities of employment. If you're free of the full-time gig and not dependent on "disability" for income, you might find something else part-time you enjoy even more.

My other advice is to stay on top of your CA19-9, Signatera, and imaging tests so if anything bad crops up, you can be on top of it right away.

Just curious -- which drug(s) are you getting in your BRCA trial?

Best wishes to ya!