Thanks for the comment! The major reason I chose against surgery (RP + r/l iliac lymph nodes) was that the surgeon said he wasn't sure he could get both lymph nodes due to my having prior right inguinal hernia repair with mesh inserted. Being uncertain of the other node, I would almost surely be on the same treatment plan I have now. Darolutamide/Nubeqa has been mentioned as the most compatible with heart issues. I am taking Eliquis for aFib that was diagnosed last summer. A gentleman I met through an online session has recurrence in multiple lymph nodes and is taking only Darolutamide. His testosterone has rebounded to 1K (high normal?) but his PSA is undetectable. He is scanned every three months and activity in the lymph nodes is no longer showing. And he says he had fatigue the first months but no side effects thereafter and has been on the med since last August. I think that's called a Grand Slam!