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Taking Orgovyx long term

Prostate Cancer | Last Active: 2 days ago | Replies (47)

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@jime51

Yes, it seems the only way to know whether other cancer cells will come out of dormancy is to stop therapy or if they become castrate resistant during ADT and the PSA rises with their growth. I'm inclined to take ADT for one year, then switch to Darolutamide for six months. If PSA is acceptably low at that point, take a therapy holiday. If PSA begins to rise with Darolutamide, add ADT back in and ask for a scan to determine whether spot radiation might eliminate whatever's still there.

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Replies to "Yes, it seems the only way to know whether other cancer cells will come out of..."

That's a fair choice.

However, for metastatic castrate-sensitive prostate cancer, studies like TITAN have shown dramatically better outcomes when you start the -lutamide at the same time as ADT instead of waiting until the ADT stops suppressing PSA. It would be worth discussing with your oncologist.