Like Dkrepid, I am very active and have tried everything. My first statin was rosuvastatin and I was fine for about 6 weeks before the muscle weakness/pain started. Switched to atorvastatin but that wasn’t any better. My cardiologist then gave me praluent and told me I would have no side effects. Praluent was the worst of all. Extreme fatigue. So bad I went to urgent care thinking something serious must be happening. And it took about 10 weeks to “recover.” My doctor then prescribed nexletol. After 3 weeks the side effects appeared. Not as bad as praluent but enough to make exercise difficult.

I have a very healthy diet, and my LDL is 90 without any meds, but the goal is to be under 70. There’s a Harvard Medicine article about how 70 is the magical number to get the best outcomes. I’m at a loss for next steps. Unfortunately I have a 30-40% bilateral blockage in my carotid arteries. Otherwise I would not think twice about it. But I would rather sacrifice quantity of life over quality than be miserable. Exercise and feeling strong are too important for my mental health.