Abiraterone alone for HT ADT therapy for PC

Posted by laccoameno5 @laccoameno5, Apr 2 7:49am

Been through almost all treatments for PC no chemo so far. Quit my second session with Lupron 2/14/2025 (side effects)), Quit the first Lupron without Abiraterone and prednisone session after a year, again SE's. Was on Lupron plus Abiraterone and Prednisone. Asked Dr. what about just continuing with the Abiraterone and Prednisone alone. Far fewer SE's. Seems there are very few if any studies on what are the outcomes with such a tack. I will be a Guinea pig . Glad to help. Others with such a situation? Experiences ?Outcome? Please respond.
Thanks

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@yongy

Here is what I have learned from it all. 2 years ago at the age of 86 they found a large tumor in my prostate but they sort of put me on a wait and hold and within a month it got out into lymph nodes including one in my chest. To those who are just learning do not ever let them do a wait and see if it is still contained in your prostate, get on it right away and go right to radiation if possible. Sometimes the tumor is located in an area where they cannot radiate it without causing bladder or bowel problems. They put me on Lupron and Zytiga and Prednisone with all the hell that goes with it. In 8 months my PSA was .02 and I quit everything. It takes a long time for the Lupron to get out of your system so the side affects continue for a while but within 4-5 months I could feel my testosterone increasing and started feeling like a man again. I never really got my muscles and weight back that I had lost. In March 2025 they did a Pet Scan and a new tumor had formed in the bottom of my prostate but it was still contained I opted for radiation but they could not do it because of the location up against my rectum. Its been ten weeks did another Pet Scan still contained and have gone on a Relugolix one pill a day regiment to reduce my testosterone once again. After 6 days only a couple of minor side affects. They should outlaw Lupron. Here is my take on the whole thing: you cannot kill cancer cells you just reduce the food it needs to survive, the testosterone. Even though your PSA may drop to less them zero the cancer is probably still hiding some where and is so small it cannot be detected and can come back at any time. We all know that all of these cancer drugs probably are way over priced and it is a huge money making machine for big pharma and they take advantage of the fact we would like to stay alive as long as we can. I know that zytiga and Lupron helped to give me diabetes and neuropathy and even affected my pancreas so that it does not work like it should. But I am still alive and I am glad so I can be with my wife as long as I can. Its a tough road. I know the American diet (processed foods and tons of sugar) does not help the body to stay healthy. Again its all about money and not helping people.

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I hope you continue to have success with Relugolix. I am five months in and have experienced virtually every side effect that the manufacturer (Orgovyx) mentions, including fatigue, hot flashes, weight gain, reduced libido, ED and did I say fatigue? I am supposed to take it for two years but will be negotiating for one if at all possible, hopefully switching to Darolutamide for a while.

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Started Orgovyx last October 2024. PSA is down from 5.5 to .1 after 6 months months. My Hematologist/Oncologist has told me to be taking it forever but I told him I will start every other day after 7 months. He said he does not recommend it but I started taking it every other day anyway. I will go for lab work after 1 month to see the changes of my PSA level.

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