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R or D alpha lipoic acid recommended?

Neuropathy | Last Active: May 21 2:03pm | Replies (7)

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@johnbishop

@joanland, The only thing my tired brain can deduce from reading a lot of research articles is that the R-ALA form is more effective that the products only labelled ALA. When the manufacturers don't specify R-ALA, the product generally contains 50% S-ALA (synthetic) which from what I've read is 40 to 60 percent less effective.
I had not read much about the DHLA form but here are a few references on the topic. I have been taking 1200 mg daily of R-ALA since 2016 but I only have numbness and no pain with my neuropathy. My neuropathy hasn't gotten any worse so I consider it helping slow or has possible stopped the progression.

-- Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
https://pmc.ncbi.nlm.nih.gov/articles/PMC6723188/
-- Alpha-Lipoic Acid as an Antioxidant Strategy for Managing Neuropathic Pain
https://pmc.ncbi.nlm.nih.gov/articles/PMC9774895/
-- R-Dihydro-Lipoic Acid The Optimal Form of Lipoic Acid
https://www.lifeextension.com/magazine/2005/2/report_lipoic

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Replies to "@joanland, The only thing my tired brain can deduce from reading a lot of research articles..."

Thank you for your very helpful response. I was put on R-Lipoic Acid shortly after being diagnosed with idiopatic peripheral neuropathy a few years ago, and I've been on it ever since. I, too, have only numbness.
At this point, ithe numbness seems to be spreading almost at a gallop. My left hand simply can't do many tasks it used to; it is losing fine motor control, which shows up primarily in the kitchen. It is very hard to hold things in or with my left hand like measuring spoons, or to separate pages in a magazine. I simply can't do it. Hands are loosing strength as well. And walking is becoming much more difficult.
I live alone and one thing I've done to help is have a woman come in one afternoon each week to help me do tasks that are difficult, and another woman comes in to clean every two weeks and occasionally to help with yard work.
Thanks for the info on alpha lipoic acid. I'll place my order for the R-form.