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@markymarkfl

Given the high rate of recurrence after Whipple, what are your thoughts on total pancreatectomy, especially for younger patients or patients with mutations predisposing them to more PDAC development?

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Replies to "Given the high rate of recurrence after Whipple, what are your thoughts on total pancreatectomy, especially..."

A more aggressive resection (total pancreatectomy, vascular resection, extended lymphadenectomy, etc…) when a standard resection obtains negative margins has not been shown to improve survival. Experienced surgeons and teams carefully plan each operation to maximize the chances of cure without increasing the chances of surgical complications or poor quality of life after surgery.