I had horrific long term side effects from Repatha and am still dealing with the damage that it caused. I was on it for four years. I thought I was just aging fast, but found out that it was the Repatha all along. The first two years went well, but then multiple problems started occurring. I started losing mobility in my hips and knees with severe pulling in my thighs. I would walk like a penguin the first 30 minutes in the morning until I could get my legs to work right. I had unnoticeable UTI's several times a year, back pain, fatigue, then snapping of a tendon in my foot for no reason, and finally severe edema in my legs and stomach. Also, I started losing my hair. When I spoke to my doctor about it, he said that the edema and some of the other mentioned issues were not listed as side effects of the drug. I did another shot and the edema came back and was severe in my abdomen and legs and my left leg seemed to drag. I was tripping all of the time. I started doing research on my own, and read that the results of the Fourier trials for the clinical studies had a 41.3 inconsistency of actual results. More people died on the drug than the placebo group. That is when I started reading about people having the same issues like myself. I was a very active person before taking this drug with no problems except for my cholesterol. The drug was insidious, as the symptoms creeped up on me slowly, so I did not realize for quite some time that it was the drug slowing me down and causing these symptoms. I finally insisted on getting off the drug. A week after I went off the drug, I fell and broke my hand and injured all of my fingers. I am still dealing with issues in my right dominant hand and can not close it. It is very painful. Now I discover that I have RA, which is an autoimmune disease. I had absolutely zero symptoms before using this drug with all of these issues and no signs of RA or autoimmune issues at all. The edema went down within the first few weeks of being off the drug...but I still feel some in my left leg at times. I had zero edema before taking this drug. The tendon in my foot that snapped (a year and a half earlier) finally healed after being off the drug for two months, no more UTI's or back pain. My hair grew back. No thigh pain and the extreme muscle pulling is gone. My energy is back and now I am having to deal with all of the long term damage that the drug has caused. My doctor found a statin that I can tolerate. Now, my doctor wants me to see a cardiologist to make sure that no damage was done. I had a stress test a couple of years before starting this drug and the stress test came out normal. I am worried that the severe abdominal edema could have done damage to my heart. Are there any people out there that have had the same issues as myself using this drug?