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Abiraterone alone for HT ADT therapy for PC

Prostate Cancer | Last Active: 6 hours ago | Replies (31)
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@tjs911

Thanks! I don't know whether it's the abiraterone (which I took in combo with digarelix for 2.5 years with no problem) or just the combo of abiraterone with the leuprolide. I suggested a possible switch to darolutamide citing the results of the Titan study ... but I think he's thinking darolutimide is a triple therapy ... with ADT and doxetaxel (as in the studies). I'm not all that interested in getting chemo. Are you on triple therapy?

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Replies to "Thanks! I don't know whether it's the abiraterone (which I took in combo with digarelix for..."
tjs911 | @tjs911 | 1 day ago

I just read results from a different study using just darolutamide and ADT.
Phase III ARANOTE Trial: These results confirm the efficacy and tolerability of darolutamide plus ADT in patients with mHSPC, demonstrating clinically and statistically significant improvement in rPFS and a favorable safety profile consistent with prior phase III darolutamide trials.
Maybe this will help move him to try the different combo?

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jeff Marchi | @jeffmarc | 1 day ago

I am a Gleason 7 with BRCA2. So far, I’ve only had one metastasis and I’ve had it zapped. My PSA has stayed undetectable for 18 months so I’m not gonna be up for chemo yet.

A short history

In 2010 I was 62 and a biopsy showed Gleason 3+4. Had surgery, after surgery they told me it was a 4+3. It was only stage two. 3.5 Years later it came back and I had radiation. 2 1/2 years later it came back and I went on Lupron. I became castrate resistant 2.5 years later and added biclautamide. 1 year later went on Zytiga, which kept my PSA down for 2 1/2 years., After some AFIB Issues I switched over to Nubeqa, The last 18 months I’ve been undetectable. I became stage four about six years ago. I did not find out I was BRCA2 Until four years ago.

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