My husband had a psa that went from 2 to 4 in a few months. Our GP referred him to a Urologist a month later who did I biopsy with a Gleason of 9 Grade 5. He has metastases in seminal vesicles and nerve bundles. This all happened within 4 months. So yes, it can happen. He immediately started radiation for 3 months. Prior he had Decipher test with results .99 which is very high which led us to add another doctor to the team who prescribed Abiraterone/prednisone and he also gets Lupron shots every 3 months for 2 years. We are 3/4s of the way through the therapy. We shall see what happens.