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Abiraterone alone for HT ADT therapy for PC

Prostate Cancer | Last Active: 1 hour ago | Replies (21)
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@pjsatz

I should have asked more specifically. I’ve seen some descriptions of Abiraterone being an irreversible inhibitor of CYP17 and wasn’t sure if that meant long term (lifetime) use of prednisone or something else would be required. Or can just live with it somehow.

Thank you,
Phil

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Replies to "I should have asked more specifically. I’ve seen some descriptions of Abiraterone being an irreversible inhibitor..."
jeff Marchi | @jeffmarc | 13 hours ago

It does not irreversibly inhibit CYP17. Some people can have Cortisol come back a little slower than others, but it is not a long-term issue.

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