this may be of interest to you. Some naturopath, not very many tho, now use prolozone for injections in the knee. .....Some, use PRP, which is a very painful injection. some use prolotherapy, which, my dr., used, and even she said that is very painful...........Prolozone was created to also regenerate the knee in osteoporosis, and supposedly either not be painful, or at least less painful. painful, isn't just at the injection site, as in prp, from the books i read, pain could last for 2 or more weeks, but then, you most probably would need to back for another treatment. I do have bone density in my knees, and am considering trying prolozone. Just haven't done it yet. when it comes to injections in my knee.........i can't seem to make that phone call to do it.................if you type in on google, which is more painful, prp or prolozone, you will get a short explanation . However, some times, the AI, gets prolozone mixed up with prolotherapy...........hope this was sort of helpful